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Gain of Function

The Gain-of-Function Experiment That Could ‘Eliminate Humans From the Face of the Earth’

by Ross Pomeroy, RealClearScience
June 20, 2024
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A Google search for “Frio Cave” makes the Uvalde County, Texas destination look like a tourists’ dream. One quickly learns that the cave is home to tens of millions of Mexican free-tailed bats, and that you can sometimes witness the flapping horde streaming out of their dark, dank home just before sunset, clouding the sky in a “once in a lifetime experience.”

But Frio Cave has a darker history that visitors websites don’t mention. More than fifty years ago, two humans contracted rabies while spelunking there.

That humans would get infected with rabies while visiting a bat-infested cave isn’t altogether surprising. Bats are a reservoir for the terrifying disease – 99% fatal to humans once symptoms – like hyperactivity, hallucinations, seizures, and fear of water – develop. A simple bite from one of the millions of bats could have transmitted a lyssavirus that triggers rabies. However, in this instance, the spelunkers apparently weren’t bitten. Rather, it seems they caught the virus from the air itself.

A team of scientists subsequently investigated. They found that rabies virus could be transmitted to animals housed in empty cages within the cave, apparently just via the atmosphere itself. Moreover, the virus was isolated from samples collected via air condensation techniques.

The episode raised a disturbing prospect. Had rabies, the deadliest virus for humankind, gone airborne?

To be clear, it had not, at least not in a manner that would result in ultra-contagious, human-to-human spread. The sheer number of rabies-carrying bats in the cave likely transformed it into a “hot-box” of infection. Rabies remains transmitted almost entirely through bites and scratches from infected animals, and it is rapidly inactivated by sunlight and heat. However, for safety, members of the general public are now only allowed to enter Frio Cave on guided tours that remain near the mouth of the cave.

That doesn’t mean that rabies virus couldn’t mutate to become transmitted through the air. It’s an RNA virus, and these are known to have high mutation rates. Indeed, scientists have found “a vast array of antigenic variants of this pathogen in a wide range of animal hosts and geographic locations.”

Moreover, as two Italian scientists wrote in a 2021 article, “Even single amino acid mutations in the proteins of Rabies virus can considerably alter its biological characteristics, for example increasing its pathogenicity and viral spread in humans, thus making the mutated virus a tangible menace for the entire mankind.”

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Another possible route for this to occur would be through a “gain-of-function” experiment, in which researchers employ gene-editing to tweak the rabies virus, making it evade current vaccines and endowing it with the ability to spread through the air like measles or influenza. Gain-of-function research has earned increased public scrutiny of late as there’s a small, outside chance it may have produced SARS-CoV-2, the virus that causes Covid-19.

Paul Offit, a professor of pediatrics at the Children’s Hospital of Philadelphia and co-inventor of a rotavirus vaccine, commented on the potential to augment rabies through gain-of-function in a recent Substack post.

“In the absence of an effective vaccine, it could eliminate humans from the face of the earth. The good news is that no one has tried to make rabies virus more contagious. But that doesn’t mean that it’s not possible or that no one would be willing to try.”

This article was originally published by RealClearScience and made available via RealClearWire.

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How to Prepare for Food Emergencies if You Don’t Have a Homestead or Bunker

In an unpredictable world, where supply chain disruptions, natural disasters, or economic instability can strike without warning, having a reliable food supply is more than just smart—it’s essential for survival. Whether you’re a “prepper” or not, we all know the golden rule: self-sufficiency is key. But what if you’re living in an apartment, working long hours, or simply don’t have the land to turn into a thriving homestead? Don’t worry; there’s a practical, effective way to build your food security without needing acres of soil or a fortified bunker.

The Ideal Prep: Building Your Own Food Empire

The ultimate dream for any serious prepper is controlling your own food production. Imagine waking up to a sprawling garden bursting with fresh vegetables, fruits, and herbs—tomatoes ripening on the vine, potatoes ready to harvest, and greens that provide nutrition year-round. Add in livestock like chickens for eggs and meat, and you’ve got a self-sustaining system that keeps your family fed no matter what chaos unfolds outside.

This approach isn’t just about calories; it’s about resilience. A well-maintained garden can yield hundreds of pounds of produce annually, while a small flock of chickens might produce dozens of eggs weekly. It’s empowering, cost-effective in the long run, and teaches invaluable skills like crop rotation, animal husbandry, and preservation techniques. If you have the space, time, and resources, starting small and scaling up is the best path to true independence.

The Reality Check: Not Everyone Can Homestead

But let’s face it—not all of us are in a position to go full homesteader. Urban dwellers might be limited to a balcony or community plot that’s far from sufficient for long-term needs. Busy professionals juggling jobs, families, and daily life often lack the hours required for daily tending. And for those in apartments, condos, or regions with harsh climates, raising livestock or maintaining a large garden simply isn’t feasible. Factors like zoning laws, soil quality, water access, or even physical limitations can make this ideal out of reach.

That’s where the frustration sets in. You want to be prepared, but without a homestead or bunker, how do you ensure your pantry doesn’t run dry during a prolonged crisis? The good news is, you don’t have to sacrifice your preparedness goals. There’s a smart, accessible alternative that bridges the gap: investing in high-quality, long-term storage food.

The Smart Alternative: Long-Term Storage Food from Heaven’s Harvest

Long-term storage food is designed for exactly these scenarios—providing nutrient-dense, shelf-stable meals that last for decades without refrigeration or special conditions. It’s the perfect solution for preppers who can’t rely on fresh production but still demand reliability and variety in their emergency stockpile.

At Heaven’s Harvest, they specialize in premium survival food kits that make preparedness effortless. Their products are crafted with the prepper mindset in mind: non-GMO, made in the USA, and packed with real ingredients that taste like home-cooked meals, not bland rations. Whether you’re stocking up for a short-term blackout or a long-haul SHTF event, our kits offer:

  • Extended Shelf Life: Up to 25 years of storage, so you can buy once and forget about rotation worries.
  • Nutritional Balance: High-protein entrees, fruits, vegetables, and dairy alternatives to keep your energy up and health intact.
  • Ease of Preparation: Just add water, and you’ve got hearty meals like beef stroganoff, chili mac, or cheesy lasagna ready in minutes—no garden weeding required.
  • Customizable Options: From individual buckets to family-sized kits, scale your supply to fit your needs and budget.
  • Peace of Mind: Sealed in durable, waterproof containers that protect against pests, moisture, and light.

Unlike generic store-bought cans that spoil quickly or lack variety, Heaven’s Harvest focuses on quality and sustainability. Our food is freeze-dried or dehydrated to lock in flavor and nutrients, ensuring you’re not just surviving but thriving. And for those concerned about allergens or dietary preferences, we offer gluten-free and vegetarian options to keep everyone covered.

Why Wait? Secure Your Food Supply Today

Preparing for food emergencies doesn’t require a homestead or bunker—it requires action. By choosing long-term storage food from Heaven’s Harvest, you’re taking control in a way that fits your lifestyle. Start small with a 72-hour kit to test the waters, or go all-in with a year’s supply for ultimate security.

Visit Heaven’s Harvest today and use code “PATRIOT” for an exclusive discount on your order. Don’t let limitations hold you back; build your resilient future, one meal at a time. Your family will thank you when it matters most.

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