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Gain of Function

The Gain-of-Function Experiment That Could ‘Eliminate Humans From the Face of the Earth’

by Ross Pomeroy, RealClearScience
June 20, 2024

A Google search for “Frio Cave” makes the Uvalde County, Texas destination look like a tourists’ dream. One quickly learns that the cave is home to tens of millions of Mexican free-tailed bats, and that you can sometimes witness the flapping horde streaming out of their dark, dank home just before sunset, clouding the sky in a “once in a lifetime experience.”

But Frio Cave has a darker history that visitors websites don’t mention. More than fifty years ago, two humans contracted rabies while spelunking there.

That humans would get infected with rabies while visiting a bat-infested cave isn’t altogether surprising. Bats are a reservoir for the terrifying disease – 99% fatal to humans once symptoms – like hyperactivity, hallucinations, seizures, and fear of water – develop. A simple bite from one of the millions of bats could have transmitted a lyssavirus that triggers rabies. However, in this instance, the spelunkers apparently weren’t bitten. Rather, it seems they caught the virus from the air itself.

A team of scientists subsequently investigated. They found that rabies virus could be transmitted to animals housed in empty cages within the cave, apparently just via the atmosphere itself. Moreover, the virus was isolated from samples collected via air condensation techniques.

The episode raised a disturbing prospect. Had rabies, the deadliest virus for humankind, gone airborne?

To be clear, it had not, at least not in a manner that would result in ultra-contagious, human-to-human spread. The sheer number of rabies-carrying bats in the cave likely transformed it into a “hot-box” of infection. Rabies remains transmitted almost entirely through bites and scratches from infected animals, and it is rapidly inactivated by sunlight and heat. However, for safety, members of the general public are now only allowed to enter Frio Cave on guided tours that remain near the mouth of the cave.

That doesn’t mean that rabies virus couldn’t mutate to become transmitted through the air. It’s an RNA virus, and these are known to have high mutation rates. Indeed, scientists have found “a vast array of antigenic variants of this pathogen in a wide range of animal hosts and geographic locations.”

Moreover, as two Italian scientists wrote in a 2021 article, “Even single amino acid mutations in the proteins of Rabies virus can considerably alter its biological characteristics, for example increasing its pathogenicity and viral spread in humans, thus making the mutated virus a tangible menace for the entire mankind.”

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Another possible route for this to occur would be through a “gain-of-function” experiment, in which researchers employ gene-editing to tweak the rabies virus, making it evade current vaccines and endowing it with the ability to spread through the air like measles or influenza. Gain-of-function research has earned increased public scrutiny of late as there’s a small, outside chance it may have produced SARS-CoV-2, the virus that causes Covid-19.

Paul Offit, a professor of pediatrics at the Children’s Hospital of Philadelphia and co-inventor of a rotavirus vaccine, commented on the potential to augment rabies through gain-of-function in a recent Substack post.

“In the absence of an effective vaccine, it could eliminate humans from the face of the earth. The good news is that no one has tried to make rabies virus more contagious. But that doesn’t mean that it’s not possible or that no one would be willing to try.”

This article was originally published by RealClearScience and made available via RealClearWire.

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Starting the Day With a Scripture-Inspired Roast Helps Center Your Thoughts on Eternal Truths Amid Temporal Pressures

The world can seem chaotic, especially right after we wake up. Many believers start their mornings reaching for something familiar — a hot cup of coffee — yet end up settling for mediocre brews that do little more than deliver a caffeine jolt. The daily grind of life, with its endless distractions, news cycles, and responsibilities, can leave even the most faithful feeling spiritually parched alongside their physical fatigue. What if your morning ritual could do more than wake you up? What if it could ground you in truth, nourish your body with exceptional quality, and quietly advance a kingdom purpose at the same time?

That’s the promise — and the reality — behind Promised Grounds Coffee. This Christian-founded company doesn’t just roast beans; it approaches every step as an act of worship and discipleship. By selecting only the top 10% of specialty-grade beans, ethically sourced from dedicated farmers in Central and South America, and small-batch roasting them with reverence in Austin, Texas, Promised Grounds delivers what many describe as the best coffee available — never burnt, never bland, but rich with origin stories and layered flavors that honor God’s creation.

From the vibrant Psalm 27 Roast (a light, bright medium option) to the bold yet peaceful 2 Timothy 1:7 Decaf, each bag carries a Scripture verse that turns your daily pour into a gentle reminder of faith. And through their Ounce Per Ounce Promise, every ounce of coffee you enjoy provides an equal ounce of clean water to families in need via partnership with Filter of Hope — literally brewing hope for body and soul, one cup at a time.

The challenge for today’s Christians runs deeper than finding a decent cup. In an age of convenience-driven consumerism, it’s easy to support companies that dilute values or remain silent on matters of faith. Many believers want their everyday choices — from what they drink to how they spend — to reflect discipleship rather than just convenience. Promised Grounds solves this by weaving Christian excellence into the entire process: beans nurtured with prayerful stewardship by farming families, roasted as an offering rather than a commodity, and packaged with Bible verses to encourage a mindset of gratitude and purpose from the first sip. Reviewers consistently praise the smooth, rich profiles — whether enjoyed black in a drip maker, iced on a warm day, or shared in fellowship — noting how the quality stands toe-to-toe with premium secular brands while delivering something far more meaningful.

This integration of faith and flavor addresses a real need in Christian households and ministries. Busy parents, church leaders, and remote workers alike report that starting the day with a Scripture-inspired roast helps center their thoughts on eternal truths amid temporal pressures. The coffee’s exceptional character — bright citrus notes in lighter roasts or deep chocolate undertones in bolder ones — comes from meticulous selection and careful roasting that respects the bean’s natural gifts rather than masking them. It’s the kind of coffee that elevates a simple quiet time, fuels productive workdays, or sparks meaningful conversations when shared at Bible studies or outreach events. And because it’s ethically sourced with integrity, every purchase supports sustainable livelihoods for farmers who treat their crops like family harvests.

For those leading churches or small groups, the impact multiplies. Promised Grounds offers bundles and options perfect for hospitality ministries, turning ordinary coffee service into an opportunity to point people toward the living water of Christ. Imagine greeting visitors with a warm cup whose very bag carries God’s Word — a subtle yet powerful witness that aligns with the Great Commission. The company’s Texas roots and commitment to “brewing hope” resonate especially with believers who value American enterprise paired with global compassion.

Of course, quality alone isn’t enough if the experience feels out of reach. Promised Grounds keeps it accessible with practical perks like free shipping on orders over $40, sample sets for discovering favorites, and thoughtful add-ons such as faith-themed mugs. Whether you prefer whole beans for fresh grinding, grounds for convenience, or even bulk options for larger households and ministries, the result is consistently superior coffee that makes discipleship feel integrated rather than added on.

As you consider how to align even the smallest habits with your walk with God, Promised Grounds Coffee stands out as a refreshing solution. It tackles the dual problems of subpar daily sustenance and disconnected consumption by offering a product that genuinely excels in taste while advancing a mission of clean water, farmer dignity, and scriptural encouragement. Believers who make the switch often describe it as more than a beverage upgrade — it becomes part of their rhythm of gratitude, a daily invitation to remember that every good gift comes from above.

If you’re ready to transform your mornings (and perhaps your church gatherings) with coffee that honors both exceptional craftsmanship and Christian values, I encourage you to explore what Promised Grounds has to offer. One sip at a time, you’ll be nourishing your body, refreshing your spirit, and participating in something far greater — all while enjoying what truly is among the best coffee available.

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